Osteocalcin, known as bone gamma-carboxyglutamic acid-containing protein (BGP), is a noncollagenous protein found in bone and dentin. It has a molecular weight of 5800 Da and contains 49 amino acids. Osteocalcin is secreted solely by osteoblasts and thought to play a role in the body’s metabolic regulation and is pro-osteoblastic, or bone-building, by nature. It is also implicated in bone mineralization and calcium ion homeostasis.

Osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release the hormone adiponectin, which increases sensitivity to insulin. A role of osteocalcin in male fertility may enhance the synthesis of testosterone


Evaluating the rate of bone loss, a significant association has consistently been demonstrated for serum osteocalcin and the rate of bone loss.

Monitoring the efficacy of antiresorptive treatment, a marked decrease in serum osteocalcin has been associated with a positive response in bone mineral density (BMD).

Estimating the risk of osteoporotic fractures, the ratio between undercarboxylated and total osteocalcin has also been associated with increased fracture risk in home-dwelling women and men.


                                                  Osteocalcin Serum Sample

Catalog Number SDC5347
Reagent Pack    100
Principle Automated Chemiluminescence Immunoassay(CLIA)
Sensitivity 0.13 ng/mL
Dynamic range       0.13-300ng/mL
Sample Type Serum
Intra-assay precision  5.44%
Inter-assay precision   9.73%
Sample Volume   80 μL

ROCHE Elecsys 2010 vs. SDi CX

Comparison of ROCHE Elecsys 2010 with SDi CX Osteocalcin using clinical samples gave the following correlations (ng/mL):

y = 0.959x + 2.301

R² = 0.988

Number sample measured: 105