Myoglobin

Myoglobin is an iron- and oxygen-binding protein found in the muscle tissue of vertebrates in general and in almost all mammals. It is related to hemoglobin, which is the iron- and oxygen-binding protein in blood, specifically in the red blood cells. Myoglobin is only found in the bloodstream after muscle injury. It is an abnormal finding, and can be diagnostically relevant when found in blood.

Heart1

Myoglobin

Myoglobin may be ordered as a cardiac biomarker, along with troponin, to help diagnose or rule out a heart attack. Levels of myoglobin start to rise within 2-3 hours of a heart attack or other muscle injury, reach their highest levels within 8-12 hours, and generally fall back to normal within one day. Myoglobin can be used for ruling out AMI in the emergency room, from 3 until 6 hours after the onset of symptoms.

Myoglobin1

 

Myoglobin was the earliest marker, and its negative predictive value (NPV) was significantly higher than for other markers from 3 to 6 hours after the onset of symptoms.

                                                    Myoglobin Serum Sample

Catalog Number SDC5173
Reagent Pack    100
Principle Automated Chemiluminescence Immunoassay(CLIA)
Sensitivity 1.3 ng/ml
Dynamic range       1.3-2000 ng/ml
Sample Type serum
Intra-assay precision  5.07%
Inter-assay precision   7.84%
Sample Volume   20 μl

Myoglobin

In a set of survey samples using SDi CX against SIEMENS Centaur give the following correlation:

y = 0.9092x – 8.8934

R² = 0.9839