IGF-I

IGF 1Human Insulin-like growth factor-I (IGF-I) is a 7.6 kD polypeptide endocrine hormone. IGF-I functions as the major mediator of growth hormone (GH)-stimulated somatic growth, as well as a mediator of GH-independent anabolic responses in many cells and tissues including muscle, bone, and cartilage tissue.

IGF-I is produced primarily by the liver as an endocrine
hormone as well as in target tissues in a paracrine/autocrine fashion. Production is stimulated by growth hormone (GH) and can be retarded by undernutrition, growth hormone insensitivity, lack of growth hormone receptors, or failures of the downstream signaling pathway post GH receptor. Approximately 98% of IGF-I is always bound to binding proteins (IGF-BP).

 

  • The test can rule out GH deficiency, if IGF-1 level is found to be normal for age and sex.
  • IGF-1 is measured to help diagnose the cause of growth abnormalities, evaluate pituitary function, and monitor treatment of GH deficiencies and excesses.
  • If surgery, drug and/or radiation therapy is necessary for a GH-producing pituitary tumor, IGF-1 levels are measured after the tumor’s removal to determine whether the entire tumor was successfully removed.
  • It may be used to monitor the effectiveness of treatment for growth hormone deficiencies and growth hormone insensitivity.

                                             IGF-I Serum Sample

Catalog Number SDC5452
Reagent Pack 100
Principle Automated Chemiluminescence Immunoassay(CLIA)
Limit of Detection 5.0ng/mL
Dynamic range  5.0-2000.0 ng/mL
Sample Type Serum
Intra-assay precision 3.97%
Inter-assay precision 7.02%

IGF