The major source of calcitonin is from the parafollicular or C cells in the thyroid gland, but it is also synthesized in a wide variety of other tissues, including the lung and intestinal tract. The function of calcition is a hormone known to participate in calcium and phosphorus metabolism. In particular, calcitonin has the ability to decrease blood calcium levels by bone and kidney. Besides, malignant tumors arising from thyroid C-cells (medullary thyroid carcinoma: MTC) usually produce elevated levels of calcitonin. Measurement of serum calcitonin is used in the follow-up of patients that have surgical removal of the thyroid gland.

B065 Calcitonin-V2

As a tumor marker to monitor medullary thyroid carcinoma, calcitonin is a sensitive tool for diagnosis medullary thyroid carcinoma.
Evaluating osteoporosis, calcitonin also appears to be a valuable aid in the management of certain types of osteoporosis. Monitor thyroid nodules, screening of calcitonin in all patients with thyroid nodules was recommended.

B065 Calcitonin2-V2

Calcitonin was evaluated the medullary thyroid carcinoma surgery, after the thyroid and duodenal surgery, the calcitonin was in a low level (The first arrow indicates the date of the thyroid surgery, the second arrow indicates the date of the duodenal surgery).


                                                    Calcitonin Serum Sample

Catalog Number SDC5345
Reagent Pack    100
Principle Automated Chemiluminescence Immunoassay(CLIA)
Sensitivity 2.0 pg/mL
Dynamic range       2.0-5000.0 pg/mL
Sample Type Serum
Intra-assay precision  5.73%
Inter-assay precision   8.74%
Sample Volume   100 μL

SDi Calcitonin vs. SIEMENS Immulite 2000

Comparison of SIEMENS Immulite with SDi Calcitonin using clinical samples gave the following correlations (pg/mL):
y = 0.896x + 3.317
R² = 0.987
Number of samples: 103